Differences in the Actions of the M3-antagonist Tolterodine and the Beta 3 Adrenoceptor Agonist Mirabegron on Non-voiding Activity in Rats with Partial Outflow Obstruction
نویسنده
چکیده
Hypothesis / aims of study Non-voiding activity (NVA) during the filling phase represents the motor component of the motor/sensory system in the bladder wall [1]. Muscarinic receptor antagonists and beta3 adrenergic receptor agonists are effective in the treatment of overactive bladder. How they do this is controversial. The aims of the present study were (i) to establish that the anticholinergic drug tolterodine and the beta3 adrenergic agonist mirabegron modulate NVA and (ii) to identify differences in the way these disparate drugs exert its therapeutic effect.
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